The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection
Identifieur interne : 000651 ( Main/Exploration ); précédent : 000650; suivant : 000652The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection
Auteurs : Sue-Jane Lin [Taïwan] ; Ming Lo [Taïwan] ; Rei-Lin Kuo [Taïwan] ; Shin-Ru Shih [Taïwan] ; David M. Ojcius [États-Unis] ; Jean Lu [Taïwan] ; Chien-Kuo Lee [Taïwan] ; Hui-Chen Chen [Taïwan] ; Meei Yun Lin [Taïwan] ; Chuen-Miin Leu [Taïwan] ; Chia-Ni Lin [Taïwan] ; Ching-Hwa Tsai [Taïwan]Source :
- Journal of Biomedical Science [ 1021-7770 ] ; 2014.
Abstract
Highly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these pathological features unfold in severe influenza infections remain unclear. Accumulation of Gr1 + CD11b + myeloid cells has been observed in highly pathogenic influenza infections but it is not clear how and why they accumulate in the severely inflamed lung. In this study, we selected this cell population as a target to investigate the extreme inflammatory response during severe influenza infection.
We established H1N1 IAV-infected mouse models using three viruses of varying pathogenicity and noted the accumulation of a defined Gr1 + CD11b + myeloid population correlating with the pathogenicity. Herein, we reported that CCR2+ inflammatory monocytes are the major cell compartments in this population. Of note, impaired clearance of the high pathogenicity virus prolonged IFN expression, leading to CCR2+ inflammatory monocytes amplifying their own recruitment via an interferon-α/β receptor 1 (IFNAR1)-triggered chemokine loop. Blockage of IFNAR1-triggered signaling or inhibition of viral replication by Oseltamivir significantly suppresses the expression of CCR2 ligands and reduced the influx of CCR2+ inflammatory monocytes. Furthermore, trafficking of CCR2+ inflammatory monocytes from the bone marrow to the lung was evidenced by a CCR2-dependent chemotaxis. Importantly, leukocyte infiltration, cytokine storm and expression of iNOS were significantly reduced in
Our results indicated that uncontrolled viral replication leads to excessive production of inflammatory innate immune responses by accumulating CCR2+ inflammatory monocytes, which contribute to the fatal outcomes of high pathogenicity virus infections.
Url:
DOI: 10.1186/s12929-014-0099-6
PubMed: 25407417
PubMed Central: 4243311
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000181
- to stream Pmc, to step Curation: 000181
- to stream Pmc, to step Checkpoint: 000440
- to stream Ncbi, to step Merge: 000B00
- to stream Ncbi, to step Curation: 000B00
- to stream Ncbi, to step Checkpoint: 000B00
- to stream Main, to step Merge: 000652
- to stream Main, to step Curation: 000651
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection</title>
<author><name sortKey="Lin, Sue Jane" sort="Lin, Sue Jane" uniqKey="Lin S" first="Sue-Jane" last="Lin">Sue-Jane Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lo, Ming" sort="Lo, Ming" uniqKey="Lo M" first="Ming" last="Lo">Ming Lo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuo, Rei Lin" sort="Kuo, Rei Lin" uniqKey="Kuo R" first="Rei-Lin" last="Kuo">Rei-Lin Kuo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ojcius, David M" sort="Ojcius, David M" uniqKey="Ojcius D" first="David M" last="Ojcius">David M. Ojcius</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">Department of Molecular Cell Biology, Health Sciences Research Institute, University of California, Merced, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Molecular Cell Biology, Health Sciences Research Institute, University of California, Merced</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lu, Jean" sort="Lu, Jean" uniqKey="Lu J" first="Jean" last="Lu">Jean Lu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Genomics Research Center, Academia Sinica, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Genomics Research Center, Academia Sinica, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Chien Kuo" sort="Lee, Chien Kuo" uniqKey="Lee C" first="Chien-Kuo" last="Lee">Chien-Kuo Lee</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Hui Chen" sort="Chen, Hui Chen" uniqKey="Chen H" first="Hui-Chen" last="Chen">Hui-Chen Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Basic Medical Science, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Meei Yun" sort="Lin, Meei Yun" uniqKey="Lin M" first="Meei Yun" last="Lin">Meei Yun Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leu, Chuen Miin" sort="Leu, Chuen Miin" uniqKey="Leu C" first="Chuen-Miin" last="Leu">Chuen-Miin Leu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff9">Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Microbiology and Immunology, National Yang-Ming University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Chia Ni" sort="Lin, Chia Ni" uniqKey="Lin C" first="Chia-Ni" last="Lin">Chia-Ni Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff10">Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou</wicri:regionArea>
<wicri:noRegion>Linkou</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsai, Ching Hwa" sort="Tsai, Ching Hwa" uniqKey="Tsai C" first="Ching-Hwa" last="Tsai">Ching-Hwa Tsai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25407417</idno>
<idno type="pmc">4243311</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243311</idno>
<idno type="RBID">PMC:4243311</idno>
<idno type="doi">10.1186/s12929-014-0099-6</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000181</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000181</idno>
<idno type="wicri:Area/Pmc/Curation">000181</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000181</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000440</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000440</idno>
<idno type="wicri:Area/Ncbi/Merge">000B00</idno>
<idno type="wicri:Area/Ncbi/Curation">000B00</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B00</idno>
<idno type="wicri:doubleKey">1021-7770:2014:Lin S:the:pathological:effects</idno>
<idno type="wicri:Area/Main/Merge">000652</idno>
<idno type="wicri:Area/Main/Curation">000651</idno>
<idno type="wicri:Area/Main/Exploration">000651</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection</title>
<author><name sortKey="Lin, Sue Jane" sort="Lin, Sue Jane" uniqKey="Lin S" first="Sue-Jane" last="Lin">Sue-Jane Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lo, Ming" sort="Lo, Ming" uniqKey="Lo M" first="Ming" last="Lo">Ming Lo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuo, Rei Lin" sort="Kuo, Rei Lin" uniqKey="Kuo R" first="Rei-Lin" last="Kuo">Rei-Lin Kuo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ojcius, David M" sort="Ojcius, David M" uniqKey="Ojcius D" first="David M" last="Ojcius">David M. Ojcius</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">Department of Molecular Cell Biology, Health Sciences Research Institute, University of California, Merced, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Molecular Cell Biology, Health Sciences Research Institute, University of California, Merced</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lu, Jean" sort="Lu, Jean" uniqKey="Lu J" first="Jean" last="Lu">Jean Lu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Genomics Research Center, Academia Sinica, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Genomics Research Center, Academia Sinica, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Chien Kuo" sort="Lee, Chien Kuo" uniqKey="Lee C" first="Chien-Kuo" last="Lee">Chien-Kuo Lee</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Hui Chen" sort="Chen, Hui Chen" uniqKey="Chen H" first="Hui-Chen" last="Chen">Hui-Chen Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Basic Medical Science, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Meei Yun" sort="Lin, Meei Yun" uniqKey="Lin M" first="Meei Yun" last="Lin">Meei Yun Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leu, Chuen Miin" sort="Leu, Chuen Miin" uniqKey="Leu C" first="Chuen-Miin" last="Leu">Chuen-Miin Leu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff9">Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Microbiology and Immunology, National Yang-Ming University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Chia Ni" sort="Lin, Chia Ni" uniqKey="Lin C" first="Chia-Ni" last="Lin">Chia-Ni Lin</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan</wicri:regionArea>
<wicri:noRegion>Tao-Yuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff10">Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou</wicri:regionArea>
<wicri:noRegion>Linkou</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsai, Ching Hwa" sort="Tsai, Ching Hwa" uniqKey="Tsai C" first="Ching-Hwa" last="Tsai">Ching-Hwa Tsai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Biomedical Science</title>
<idno type="ISSN">1021-7770</idno>
<idno type="eISSN">1423-0127</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Highly pathogenic influenza viruses cause high levels of morbidity, including excessive infiltration of leukocytes into the lungs, high viral loads and a cytokine storm. However, the details of how these pathological features unfold in severe influenza infections remain unclear. Accumulation of Gr1 + CD11b + myeloid cells has been observed in highly pathogenic influenza infections but it is not clear how and why they accumulate in the severely inflamed lung. In this study, we selected this cell population as a target to investigate the extreme inflammatory response during severe influenza infection.</p>
</sec>
<sec><title>Results</title>
<p>We established H1N1 IAV-infected mouse models using three viruses of varying pathogenicity and noted the accumulation of a defined Gr1 + CD11b + myeloid population correlating with the pathogenicity. Herein, we reported that CCR2+ inflammatory monocytes are the major cell compartments in this population. Of note, impaired clearance of the high pathogenicity virus prolonged IFN expression, leading to CCR2+ inflammatory monocytes amplifying their own recruitment via an interferon-α/β receptor 1 (IFNAR1)-triggered chemokine loop. Blockage of IFNAR1-triggered signaling or inhibition of viral replication by Oseltamivir significantly suppresses the expression of CCR2 ligands and reduced the influx of CCR2+ inflammatory monocytes. Furthermore, trafficking of CCR2+ inflammatory monocytes from the bone marrow to the lung was evidenced by a CCR2-dependent chemotaxis. Importantly, leukocyte infiltration, cytokine storm and expression of iNOS were significantly reduced in <italic>CCR2−/−</italic>
mice lacking infiltrating CCR2+ inflammatory monocytes, enhancing the survival of the infected mice.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our results indicated that uncontrolled viral replication leads to excessive production of inflammatory innate immune responses by accumulating CCR2+ inflammatory monocytes, which contribute to the fatal outcomes of high pathogenicity virus infections.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Graham Rowe, D" uniqKey="Graham Rowe D">D Graham-Rowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Shen, Y" uniqKey="Shen Y">Y Shen</name>
</author>
<author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Duan, L" uniqKey="Duan L">L Duan</name>
</author>
<author><name sortKey="Cheung, Cl" uniqKey="Cheung C">CL Cheung</name>
</author>
<author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name>
</author>
<author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name>
</author>
<author><name sortKey="Leung, Cy" uniqKey="Leung C">CY Leung</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Hong, W" uniqKey="Hong W">W Hong</name>
</author>
<author><name sortKey="Chai, Y" uniqKey="Chai Y">Y Chai</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name>
</author>
<author><name sortKey="Liang, H" uniqKey="Liang H">H Liang</name>
</author>
<author><name sortKey="Ou, Z" uniqKey="Ou Z">Z Ou</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Farooqui, A" uniqKey="Farooqui A">A Farooqui</name>
</author>
<author><name sortKey="Kelvin, Dj" uniqKey="Kelvin D">DJ Kelvin</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Smith, Dk" uniqKey="Smith D">DK Smith</name>
</author>
<author><name sortKey="Pybus, Og" uniqKey="Pybus O">OG Pybus</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
<author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
<author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perrone, La" uniqKey="Perrone L">LA Perrone</name>
</author>
<author><name sortKey="Plowden, Jk" uniqKey="Plowden J">JK Plowden</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name>
</author>
<author><name sortKey="Jones, Sm" uniqKey="Jones S">SM Jones</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
<author><name sortKey="Copps, J" uniqKey="Copps J">J Copps</name>
</author>
<author><name sortKey="Ebihara, H" uniqKey="Ebihara H">H Ebihara</name>
</author>
<author><name sortKey="Hatta, Y" uniqKey="Hatta Y">Y Hatta</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Halfmann, P" uniqKey="Halfmann P">P Halfmann</name>
</author>
<author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
<author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
<author><name sortKey="Alimonti, Jb" uniqKey="Alimonti J">JB Alimonti</name>
</author>
<author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baskin, Cr" uniqKey="Baskin C">CR Baskin</name>
</author>
<author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H Bielefeldt-Ohmann</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Sabourin, Pj" uniqKey="Sabourin P">PJ Sabourin</name>
</author>
<author><name sortKey="Long, Jp" uniqKey="Long J">JP Long</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
<author><name sortKey="Tolnay, Ae" uniqKey="Tolnay A">AE Tolnay</name>
</author>
<author><name sortKey="Albrecht, R" uniqKey="Albrecht R">R Albrecht</name>
</author>
<author><name sortKey="Pyles, Ja" uniqKey="Pyles J">JA Pyles</name>
</author>
<author><name sortKey="Olson, Ph" uniqKey="Olson P">PH Olson</name>
</author>
<author><name sortKey="Aicher, Ld" uniqKey="Aicher L">LD Aicher</name>
</author>
<author><name sortKey="Rosenzweig, Er" uniqKey="Rosenzweig E">ER Rosenzweig</name>
</author>
<author><name sortKey="Murali Krishna, K" uniqKey="Murali Krishna K">K Murali-Krishna</name>
</author>
<author><name sortKey="Clark, Ea" uniqKey="Clark E">EA Clark</name>
</author>
<author><name sortKey="Kotur, Ms" uniqKey="Kotur M">MS Kotur</name>
</author>
<author><name sortKey="Fornek, Jl" uniqKey="Fornek J">JL Fornek</name>
</author>
<author><name sortKey="Proll, S" uniqKey="Proll S">S Proll</name>
</author>
<author><name sortKey="Palermo, Re" uniqKey="Palermo R">RE Palermo</name>
</author>
<author><name sortKey="Sabourin, Cl" uniqKey="Sabourin C">CL Sabourin</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R Salomon</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perrone, La" uniqKey="Perrone L">LA Perrone</name>
</author>
<author><name sortKey="Szretter, Kj" uniqKey="Szretter K">KJ Szretter</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
<author><name sortKey="Mizgerd, Jp" uniqKey="Mizgerd J">JP Mizgerd</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Bp" uniqKey="Chen B">BP Chen</name>
</author>
<author><name sortKey="Kuziel, Wa" uniqKey="Kuziel W">WA Kuziel</name>
</author>
<author><name sortKey="Lane, Te" uniqKey="Lane T">TE Lane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Jk" uniqKey="Lim J">JK Lim</name>
</author>
<author><name sortKey="Obara, Cj" uniqKey="Obara C">CJ Obara</name>
</author>
<author><name sortKey="Rivollier, A" uniqKey="Rivollier A">A Rivollier</name>
</author>
<author><name sortKey="Pletnev, Ag" uniqKey="Pletnev A">AG Pletnev</name>
</author>
<author><name sortKey="Kelsall, Bl" uniqKey="Kelsall B">BL Kelsall</name>
</author>
<author><name sortKey="Murphy, Pm" uniqKey="Murphy P">PM Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawson, Tc" uniqKey="Dawson T">TC Dawson</name>
</author>
<author><name sortKey="Beck, Ma" uniqKey="Beck M">MA Beck</name>
</author>
<author><name sortKey="Kuziel, Wa" uniqKey="Kuziel W">WA Kuziel</name>
</author>
<author><name sortKey="Henderson, F" uniqKey="Henderson F">F Henderson</name>
</author>
<author><name sortKey="Maeda, N" uniqKey="Maeda N">N Maeda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Kl" uniqKey="Lin K">KL Lin</name>
</author>
<author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name>
</author>
<author><name sortKey="Nakano, H" uniqKey="Nakano H">H Nakano</name>
</author>
<author><name sortKey="Ramsburg, E" uniqKey="Ramsburg E">E Ramsburg</name>
</author>
<author><name sortKey="Gunn, Md" uniqKey="Gunn M">MD Gunn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iijima, N" uniqKey="Iijima N">N Iijima</name>
</author>
<author><name sortKey="Mattei, Lm" uniqKey="Mattei L">LM Mattei</name>
</author>
<author><name sortKey="Iwasaki, A" uniqKey="Iwasaki A">A Iwasaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daley Bauer, Lp" uniqKey="Daley Bauer L">LP Daley-Bauer</name>
</author>
<author><name sortKey="Wynn, Gm" uniqKey="Wynn G">GM Wynn</name>
</author>
<author><name sortKey="Mocarski, Es" uniqKey="Mocarski E">ES Mocarski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Norris, Ba" uniqKey="Norris B">BA Norris</name>
</author>
<author><name sortKey="Uebelhoer, Ls" uniqKey="Uebelhoer L">LS Uebelhoer</name>
</author>
<author><name sortKey="Nakaya, Hi" uniqKey="Nakaya H">HI Nakaya</name>
</author>
<author><name sortKey="Price, Aa" uniqKey="Price A">AA Price</name>
</author>
<author><name sortKey="Grakoui, A" uniqKey="Grakoui A">A Grakoui</name>
</author>
<author><name sortKey="Pulendran, B" uniqKey="Pulendran B">B Pulendran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuo, Rl" uniqKey="Kuo R">RL Kuo</name>
</author>
<author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Ito, H" uniqKey="Ito H">H Ito</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Goto, H" uniqKey="Goto H">H Goto</name>
</author>
<author><name sortKey="Gao, P" uniqKey="Gao P">P Gao</name>
</author>
<author><name sortKey="Hughes, M" uniqKey="Hughes M">M Hughes</name>
</author>
<author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name>
</author>
<author><name sortKey="Donis, R" uniqKey="Donis R">R Donis</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Hobom, G" uniqKey="Hobom G">G Hobom</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manicassamy, B" uniqKey="Manicassamy B">B Manicassamy</name>
</author>
<author><name sortKey="Manicassamy, S" uniqKey="Manicassamy S">S Manicassamy</name>
</author>
<author><name sortKey="Belicha Villanueva, A" uniqKey="Belicha Villanueva A">A Belicha-Villanueva</name>
</author>
<author><name sortKey="Pisanelli, G" uniqKey="Pisanelli G">G Pisanelli</name>
</author>
<author><name sortKey="Pulendran, B" uniqKey="Pulendran B">B Pulendran</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Babcock, Aa" uniqKey="Babcock A">AA Babcock</name>
</author>
<author><name sortKey="Toft Hansen, H" uniqKey="Toft Hansen H">H Toft-Hansen</name>
</author>
<author><name sortKey="Owens, T" uniqKey="Owens T">T Owens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seo, Su" uniqKey="Seo S">SU Seo</name>
</author>
<author><name sortKey="Kwon, Hj" uniqKey="Kwon H">HJ Kwon</name>
</author>
<author><name sortKey="Ko, Hj" uniqKey="Ko H">HJ Ko</name>
</author>
<author><name sortKey="Byun, Yh" uniqKey="Byun Y">YH Byun</name>
</author>
<author><name sortKey="Seong, Bl" uniqKey="Seong B">BL Seong</name>
</author>
<author><name sortKey="Uematsu, S" uniqKey="Uematsu S">S Uematsu</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name>
</author>
<author><name sortKey="Kweon, Mn" uniqKey="Kweon M">MN Kweon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Weerd, Na" uniqKey="De Weerd N">NA de Weerd</name>
</author>
<author><name sortKey="Vivian, Jp" uniqKey="Vivian J">JP Vivian</name>
</author>
<author><name sortKey="Nguyen, Tk" uniqKey="Nguyen T">TK Nguyen</name>
</author>
<author><name sortKey="Mangan, Ne" uniqKey="Mangan N">NE Mangan</name>
</author>
<author><name sortKey="Gould, Ja" uniqKey="Gould J">JA Gould</name>
</author>
<author><name sortKey="Braniff, Sj" uniqKey="Braniff S">SJ Braniff</name>
</author>
<author><name sortKey="Zaker Tabrizi, L" uniqKey="Zaker Tabrizi L">L Zaker-Tabrizi</name>
</author>
<author><name sortKey="Fung, Ky" uniqKey="Fung K">KY Fung</name>
</author>
<author><name sortKey="Forster, Sc" uniqKey="Forster S">SC Forster</name>
</author>
<author><name sortKey="Beddoe, T" uniqKey="Beddoe T">T Beddoe</name>
</author>
<author><name sortKey="Reid, Hh" uniqKey="Reid H">HH Reid</name>
</author>
<author><name sortKey="Rossjohn, J" uniqKey="Rossjohn J">J Rossjohn</name>
</author>
<author><name sortKey="Hertzog, Pj" uniqKey="Hertzog P">PJ Hertzog</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Serbina, Nv" uniqKey="Serbina N">NV Serbina</name>
</author>
<author><name sortKey="Pamer, Eg" uniqKey="Pamer E">EG Pamer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsou, Cl" uniqKey="Tsou C">CL Tsou</name>
</author>
<author><name sortKey="Peters, W" uniqKey="Peters W">W Peters</name>
</author>
<author><name sortKey="Si, Y" uniqKey="Si Y">Y Si</name>
</author>
<author><name sortKey="Slaymaker, S" uniqKey="Slaymaker S">S Slaymaker</name>
</author>
<author><name sortKey="Aslanian, Am" uniqKey="Aslanian A">AM Aslanian</name>
</author>
<author><name sortKey="Weisberg, Sp" uniqKey="Weisberg S">SP Weisberg</name>
</author>
<author><name sortKey="Mack, M" uniqKey="Mack M">M Mack</name>
</author>
<author><name sortKey="Charo, If" uniqKey="Charo I">IF Charo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karupiah, G" uniqKey="Karupiah G">G Karupiah</name>
</author>
<author><name sortKey="Chen, Jh" uniqKey="Chen J">JH Chen</name>
</author>
<author><name sortKey="Mahalingam, S" uniqKey="Mahalingam S">S Mahalingam</name>
</author>
<author><name sortKey="Nathan, Cf" uniqKey="Nathan C">CF Nathan</name>
</author>
<author><name sortKey="Macmicking, Jd" uniqKey="Macmicking J">JD MacMicking</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hofmann, P" uniqKey="Hofmann P">P Hofmann</name>
</author>
<author><name sortKey="Sprenger, H" uniqKey="Sprenger H">H Sprenger</name>
</author>
<author><name sortKey="Kaufmann, A" uniqKey="Kaufmann A">A Kaufmann</name>
</author>
<author><name sortKey="Bender, A" uniqKey="Bender A">A Bender</name>
</author>
<author><name sortKey="Hasse, C" uniqKey="Hasse C">C Hasse</name>
</author>
<author><name sortKey="Nain, M" uniqKey="Nain M">M Nain</name>
</author>
<author><name sortKey="Gemsa, D" uniqKey="Gemsa D">D Gemsa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hermesh, T" uniqKey="Hermesh T">T Hermesh</name>
</author>
<author><name sortKey="Moltedo, B" uniqKey="Moltedo B">B Moltedo</name>
</author>
<author><name sortKey="Moran, Tm" uniqKey="Moran T">TM Moran</name>
</author>
<author><name sortKey="Lopez, Cb" uniqKey="Lopez C">CB Lopez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K Honda</name>
</author>
<author><name sortKey="Takaoka, A" uniqKey="Takaoka A">A Takaoka</name>
</author>
<author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T Taniguchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gough, Dj" uniqKey="Gough D">DJ Gough</name>
</author>
<author><name sortKey="Messina, Nl" uniqKey="Messina N">NL Messina</name>
</author>
<author><name sortKey="Clarke, Cj" uniqKey="Clarke C">CJ Clarke</name>
</author>
<author><name sortKey="Johnstone, Rw" uniqKey="Johnstone R">RW Johnstone</name>
</author>
<author><name sortKey="Levy, De" uniqKey="Levy D">DE Levy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mok, Ck" uniqKey="Mok C">CK Mok</name>
</author>
<author><name sortKey="Lee, Hh" uniqKey="Lee H">HH Lee</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Sia, Sf" uniqKey="Sia S">SF Sia</name>
</author>
<author><name sortKey="Lestra, M" uniqKey="Lestra M">M Lestra</name>
</author>
<author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Peiris, Jm" uniqKey="Peiris J">JM Peiris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shahangian, A" uniqKey="Shahangian A">A Shahangian</name>
</author>
<author><name sortKey="Chow, Ek" uniqKey="Chow E">EK Chow</name>
</author>
<author><name sortKey="Tian, X" uniqKey="Tian X">X Tian</name>
</author>
<author><name sortKey="Kang, Jr" uniqKey="Kang J">JR Kang</name>
</author>
<author><name sortKey="Ghaffari, A" uniqKey="Ghaffari A">A Ghaffari</name>
</author>
<author><name sortKey="Liu, Sy" uniqKey="Liu S">SY Liu</name>
</author>
<author><name sortKey="Belperio, Ja" uniqKey="Belperio J">JA Belperio</name>
</author>
<author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name>
</author>
<author><name sortKey="Deng, Jc" uniqKey="Deng J">JC Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wareing, Md" uniqKey="Wareing M">MD Wareing</name>
</author>
<author><name sortKey="Lyon, A" uniqKey="Lyon A">A Lyon</name>
</author>
<author><name sortKey="Inglis, C" uniqKey="Inglis C">C Inglis</name>
</author>
<author><name sortKey="Giannoni, F" uniqKey="Giannoni F">F Giannoni</name>
</author>
<author><name sortKey="Charo, I" uniqKey="Charo I">I Charo</name>
</author>
<author><name sortKey="Sarawar, Sr" uniqKey="Sarawar S">SR Sarawar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hogner, K" uniqKey="Hogner K">K Hogner</name>
</author>
<author><name sortKey="Wolff, T" uniqKey="Wolff T">T Wolff</name>
</author>
<author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S Pleschka</name>
</author>
<author><name sortKey="Plog, S" uniqKey="Plog S">S Plog</name>
</author>
<author><name sortKey="Gruber, Ad" uniqKey="Gruber A">AD Gruber</name>
</author>
<author><name sortKey="Kalinke, U" uniqKey="Kalinke U">U Kalinke</name>
</author>
<author><name sortKey="Walmrath, Hd" uniqKey="Walmrath H">HD Walmrath</name>
</author>
<author><name sortKey="Bodner, J" uniqKey="Bodner J">J Bodner</name>
</author>
<author><name sortKey="Gattenlohner, S" uniqKey="Gattenlohner S">S Gattenlohner</name>
</author>
<author><name sortKey="Lewe Schlosser, P" uniqKey="Lewe Schlosser P">P Lewe-Schlosser</name>
</author>
<author><name sortKey="Matrosovich, M" uniqKey="Matrosovich M">M Matrosovich</name>
</author>
<author><name sortKey="Seeger, W" uniqKey="Seeger W">W Seeger</name>
</author>
<author><name sortKey="Lohmeyer, J" uniqKey="Lohmeyer J">J Lohmeyer</name>
</author>
<author><name sortKey="Herold, S" uniqKey="Herold S">S Herold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujikura, D" uniqKey="Fujikura D">D Fujikura</name>
</author>
<author><name sortKey="Chiba, S" uniqKey="Chiba S">S Chiba</name>
</author>
<author><name sortKey="Muramatsu, D" uniqKey="Muramatsu D">D Muramatsu</name>
</author>
<author><name sortKey="Kazumata, M" uniqKey="Kazumata M">M Kazumata</name>
</author>
<author><name sortKey="Nakayama, Y" uniqKey="Nakayama Y">Y Nakayama</name>
</author>
<author><name sortKey="Kawai, T" uniqKey="Kawai T">T Kawai</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name>
</author>
<author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name>
</author>
<author><name sortKey="Miyazaki, T" uniqKey="Miyazaki T">T Miyazaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name>
</author>
<author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name>
</author>
<author><name sortKey="Cahalan, S" uniqKey="Cahalan S">S Cahalan</name>
</author>
<author><name sortKey="Fremgen, Dm" uniqKey="Fremgen D">DM Fremgen</name>
</author>
<author><name sortKey="Roberts, E" uniqKey="Roberts E">E Roberts</name>
</author>
<author><name sortKey="Scott, F" uniqKey="Scott F">F Scott</name>
</author>
<author><name sortKey="Martinborough, E" uniqKey="Martinborough E">E Martinborough</name>
</author>
<author><name sortKey="Peach, R" uniqKey="Peach R">R Peach</name>
</author>
<author><name sortKey="Oldstone, Mb" uniqKey="Oldstone M">MB Oldstone</name>
</author>
<author><name sortKey="Rosen, H" uniqKey="Rosen H">H Rosen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jia, T" uniqKey="Jia T">T Jia</name>
</author>
<author><name sortKey="Leiner, I" uniqKey="Leiner I">I Leiner</name>
</author>
<author><name sortKey="Dorothee, G" uniqKey="Dorothee G">G Dorothee</name>
</author>
<author><name sortKey="Brandl, K" uniqKey="Brandl K">K Brandl</name>
</author>
<author><name sortKey="Pamer, Eg" uniqKey="Pamer E">EG Pamer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ioannidis, I" uniqKey="Ioannidis I">I Ioannidis</name>
</author>
<author><name sortKey="Mcnally, B" uniqKey="Mcnally B">B McNally</name>
</author>
<author><name sortKey="Willette, M" uniqKey="Willette M">M Willette</name>
</author>
<author><name sortKey="Peeples, Me" uniqKey="Peeples M">ME Peeples</name>
</author>
<author><name sortKey="Chaussabel, D" uniqKey="Chaussabel D">D Chaussabel</name>
</author>
<author><name sortKey="Durbin, Je" uniqKey="Durbin J">JE Durbin</name>
</author>
<author><name sortKey="Ramilo, O" uniqKey="Ramilo O">O Ramilo</name>
</author>
<author><name sortKey="Mejias, A" uniqKey="Mejias A">A Mejias</name>
</author>
<author><name sortKey="Flano, E" uniqKey="Flano E">E Flano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name>
</author>
<author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name>
</author>
<author><name sortKey="Rice, S" uniqKey="Rice S">S Rice</name>
</author>
<author><name sortKey="Rosen, H" uniqKey="Rosen H">H Rosen</name>
</author>
<author><name sortKey="Oldstone, Mb" uniqKey="Oldstone M">MB Oldstone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jia, T" uniqKey="Jia T">T Jia</name>
</author>
<author><name sortKey="Serbina, Nv" uniqKey="Serbina N">NV Serbina</name>
</author>
<author><name sortKey="Brandl, K" uniqKey="Brandl K">K Brandl</name>
</author>
<author><name sortKey="Zhong, Mx" uniqKey="Zhong M">MX Zhong</name>
</author>
<author><name sortKey="Leiner, Im" uniqKey="Leiner I">IM Leiner</name>
</author>
<author><name sortKey="Charo, If" uniqKey="Charo I">IF Charo</name>
</author>
<author><name sortKey="Pamer, Eg" uniqKey="Pamer E">EG Pamer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Helft, J" uniqKey="Helft J">J Helft</name>
</author>
<author><name sortKey="Manicassamy, B" uniqKey="Manicassamy B">B Manicassamy</name>
</author>
<author><name sortKey="Guermonprez, P" uniqKey="Guermonprez P">P Guermonprez</name>
</author>
<author><name sortKey="Hashimoto, D" uniqKey="Hashimoto D">D Hashimoto</name>
</author>
<author><name sortKey="Silvin, A" uniqKey="Silvin A">A Silvin</name>
</author>
<author><name sortKey="Agudo, J" uniqKey="Agudo J">J Agudo</name>
</author>
<author><name sortKey="Brown, Bd" uniqKey="Brown B">BD Brown</name>
</author>
<author><name sortKey="Schmolke, M" uniqKey="Schmolke M">M Schmolke</name>
</author>
<author><name sortKey="Miller, Jc" uniqKey="Miller J">JC Miller</name>
</author>
<author><name sortKey="Leboeuf, M" uniqKey="Leboeuf M">M Leboeuf</name>
</author>
<author><name sortKey="Leboeuf, M" uniqKey="Leboeuf M">M Leboeuf</name>
</author>
<author><name sortKey="Murphy, Km" uniqKey="Murphy K">KM Murphy</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
<author><name sortKey="Merad, M" uniqKey="Merad M">M Merad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pang, Ik" uniqKey="Pang I">IK Pang</name>
</author>
<author><name sortKey="Pillai, Ps" uniqKey="Pillai P">PS Pillai</name>
</author>
<author><name sortKey="Iwasaki, A" uniqKey="Iwasaki A">A Iwasaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Long, Jp" uniqKey="Long J">JP Long</name>
</author>
<author><name sortKey="Kotur, Ms" uniqKey="Kotur M">MS Kotur</name>
</author>
<author><name sortKey="Stark, Gv" uniqKey="Stark G">GV Stark</name>
</author>
<author><name sortKey="Warren, Rl" uniqKey="Warren R">RL Warren</name>
</author>
<author><name sortKey="Kasoji, M" uniqKey="Kasoji M">M Kasoji</name>
</author>
<author><name sortKey="Craft, Jl" uniqKey="Craft J">JL Craft</name>
</author>
<author><name sortKey="Albrecht, Ra" uniqKey="Albrecht R">RA Albrecht</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Waters, Km" uniqKey="Waters K">KM Waters</name>
</author>
<author><name sortKey="Vasconcelos, D" uniqKey="Vasconcelos D">D Vasconcelos</name>
</author>
<author><name sortKey="Sabourin, Pj" uniqKey="Sabourin P">PJ Sabourin</name>
</author>
<author><name sortKey="Bresler, Hs" uniqKey="Bresler H">HS Bresler</name>
</author>
<author><name sortKey="Sabourin, Cl" uniqKey="Sabourin C">CL Sabourin</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Taïwan</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Lin, Sue Jane" sort="Lin, Sue Jane" uniqKey="Lin S" first="Sue-Jane" last="Lin">Sue-Jane Lin</name>
</noRegion>
<name sortKey="Chen, Hui Chen" sort="Chen, Hui Chen" uniqKey="Chen H" first="Hui-Chen" last="Chen">Hui-Chen Chen</name>
<name sortKey="Kuo, Rei Lin" sort="Kuo, Rei Lin" uniqKey="Kuo R" first="Rei-Lin" last="Kuo">Rei-Lin Kuo</name>
<name sortKey="Kuo, Rei Lin" sort="Kuo, Rei Lin" uniqKey="Kuo R" first="Rei-Lin" last="Kuo">Rei-Lin Kuo</name>
<name sortKey="Kuo, Rei Lin" sort="Kuo, Rei Lin" uniqKey="Kuo R" first="Rei-Lin" last="Kuo">Rei-Lin Kuo</name>
<name sortKey="Lee, Chien Kuo" sort="Lee, Chien Kuo" uniqKey="Lee C" first="Chien-Kuo" last="Lee">Chien-Kuo Lee</name>
<name sortKey="Leu, Chuen Miin" sort="Leu, Chuen Miin" uniqKey="Leu C" first="Chuen-Miin" last="Leu">Chuen-Miin Leu</name>
<name sortKey="Lin, Chia Ni" sort="Lin, Chia Ni" uniqKey="Lin C" first="Chia-Ni" last="Lin">Chia-Ni Lin</name>
<name sortKey="Lin, Chia Ni" sort="Lin, Chia Ni" uniqKey="Lin C" first="Chia-Ni" last="Lin">Chia-Ni Lin</name>
<name sortKey="Lin, Meei Yun" sort="Lin, Meei Yun" uniqKey="Lin M" first="Meei Yun" last="Lin">Meei Yun Lin</name>
<name sortKey="Lin, Sue Jane" sort="Lin, Sue Jane" uniqKey="Lin S" first="Sue-Jane" last="Lin">Sue-Jane Lin</name>
<name sortKey="Lin, Sue Jane" sort="Lin, Sue Jane" uniqKey="Lin S" first="Sue-Jane" last="Lin">Sue-Jane Lin</name>
<name sortKey="Lo, Ming" sort="Lo, Ming" uniqKey="Lo M" first="Ming" last="Lo">Ming Lo</name>
<name sortKey="Lu, Jean" sort="Lu, Jean" uniqKey="Lu J" first="Jean" last="Lu">Jean Lu</name>
<name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
<name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
<name sortKey="Shih, Shin Ru" sort="Shih, Shin Ru" uniqKey="Shih S" first="Shin-Ru" last="Shih">Shin-Ru Shih</name>
<name sortKey="Tsai, Ching Hwa" sort="Tsai, Ching Hwa" uniqKey="Tsai C" first="Ching-Hwa" last="Tsai">Ching-Hwa Tsai</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Ojcius, David M" sort="Ojcius, David M" uniqKey="Ojcius D" first="David M" last="Ojcius">David M. Ojcius</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000651 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000651 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4243311 |texte= The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25407417" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |